Hypertonic and hyperoncotic resuscitation from severe hemorrhagic shock in dogs: a comparative study.
Crit Care Med
; 17(3): 261-4, 1989 Mar.
Article
em En
| MEDLINE
| ID: mdl-2465867
Single bolus injections of hypertonic (7.5%) NaCl (H), hyperoncotic (6%) dextran-70 (D), or of their combination (HD) were given to severely bled (54.2 +/- 1.3 ml/kg) anesthetized dogs. Two shock procedures (30 or 60 min at 35 mm Hg) were tested. Survival was highest (11/12) after HD, lower (9/12) after H, and lowest (7/12) after D; it was higher (15/18 vs. 12/18) after the shorter vs. longer shock procedure. Cardiac index (CI) was restored to 83%-104% of prehemorrhage levels immediately after HD or H; 3 h later it was down to 67%-71% of control; after D, CI was stable at 41% to 50% of control; no differences in the relative performances of the agents tested in the 30 or 60-min shock durations. Arterial pressure recovered to near control levels in all groups; consequently, systemic vascular resistance was reduced after H and HD, but increased after D. Plasma volume recovered to 95% of control after H, 105% of control after HD, but only to 80% after D; however, the response to H was transient. Metabolic acidosis was partially reverted by all solutions. Plasma Na+ was transiently raised by H and HD. Overall differences detected between H vs. HD tend to favor HD as a resuscitative solution.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ressuscitação
/
Solução Salina Hipertônica
/
Choque Hemorrágico
/
Cloreto de Sódio
/
Dextranos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Crit Care Med
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos