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Anti-hepatitis C virus treatment may prevent the progression of liver fibrosis in non-responder human immunodeficiency virus/hepatitis C virus coinfected patients.
Sagnelli, Caterina; Uberti-Foppa, Caterina; Galli, Laura; Pasquale, Giuseppe; Coppola, Nicola; Albarello, Luca; Doglioni, Carlo; Lazzarin, Adriano; Sagnelli, Evangelista.
Afiliação
  • Sagnelli C; Clinic of Infectious Diseases, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy; Experimental Medicine and Surgery "F. Magrassi e A. Lanzara", Second University of Naples, Naples, Italy.
  • Uberti-Foppa C; Clinic of Infectious Diseases, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy.
  • Galli L; Clinic of Infectious Diseases, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy.
  • Pasquale G; Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy.
  • Coppola N; Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy.
  • Albarello L; Department of Pathology, San Raffaele Scientific Institute, Milan, Italy.
  • Doglioni C; Department of Pathology, San Raffaele Scientific Institute, Milan, Italy.
  • Lazzarin A; Clinic of Infectious Diseases, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy.
  • Sagnelli E; Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, Italy. Electronic address: evangelista.sagnelli@unina2.it.
Braz J Infect Dis ; 18(2): 164-9, 2014.
Article em En | MEDLINE | ID: mdl-24650995
AIM: To evaluate changes in liver histology in patients with human immunodeficiency virus/hepatitis C virus coinfection non-responders to a suboptimal Interferon+Ribavirine regimen. MATERIALS AND METHODS: We investigated 49 patients with two sequential liver biopsies: 18 were non-responders to Interferon+Ribavirine treatment (Group hepatitis C virus Rx) administered after the 1st liver biopsy who underwent a 2nd liver biopsy after a median period of 3.92 year and 31 were patients who remained untreated for hepatitis C virus disease (Group hepatitis C virus untreated) after the 1st liver biopsy because of refusal and underwent a 2nd liver biopsy after a median period of 5.05-years. Most patients in both groups were under highly active antiretroviral therapy. At the time of 1st liver biopsy similar degrees of necro-inflammation, fibrosis and steatosis were observed in both groups. Changes in liver lesions between 1st and 2nd liver biopsys were adjusted for different intervals between liver biopsys by a mathematic formula. RESULTS: Liver fibrosis did not change in 88.9% of patients in Group hepatitis C virus Rx and in 77.4% in Group hepatitis C virus untreated. A marked deterioration in liver fibrosis was observed in 5 (16%) patients in Group hepatitis C virus untreated and in none in Group hepatitis C virus treated. Necro-inflammation and steatosis remained substantially unchanged in both groups. CONCLUSION: Liver histology remained substantially unchanged in human immunodeficiency virus/hepatitis C virus patients non-responder to anti-hepatitis C virus therapy over 4 years observation, suggesting an effective anti-hepatitis C virus early treatment for all hepatitis C virus/human immunodeficiency virus coinfected patients who can reasonably tolerate therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Ribavirina / Infecções por HIV / Interferon-alfa / Hepatite C / Coinfecção / Fígado / Cirrose Hepática Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Itália País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Ribavirina / Infecções por HIV / Interferon-alfa / Hepatite C / Coinfecção / Fígado / Cirrose Hepática Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Itália País de publicação: Brasil