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Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population.
Cai, G J; He, G P; Huang, Z Y; Qi, C P.
Afiliação
  • Cai GJ; Department of Cardiology, Wujin hospital, Jiangsu University, Changzhou, Jiangsu Province, China cgj982@126.com.
  • He GP; Department of Cardiology, Wujin hospital, Jiangsu University, Changzhou, Jiangsu Province, China.
  • Huang ZY; Department of Pediatrics, NO.2 Hospital of Changzhou, Jiangsu, China.
  • Qi CP; Department of Central lab, Wujin hospital, Jiangsu University, Changzhou, Jiangsu Province, China.
Genet Mol Res ; 13(1): 1059-69, 2014 Feb 20.
Article em En | MEDLINE | ID: mdl-24634127
A growing body of evidence suggests that the 584C/T polymorphism in the endothelial lipase (EL) gene contributes to the process of coronary artery disease (CAD). The present study aimed to reveal the potential relationship between the EL 584C/T gene polymorphism and early-onset CAD, CAD severity, and lipid levels in a Chinese Han population. Participants comprised 135 early-onset CAD patients and 166 controls. EL 584C/T genotypic and allelic frequencies were detected by PCR. The frequencies of the CC, CT, and TT genotypes were 58.4, 38.6, and 3.0%, respectively, within the control group, and 62.2, 33.3, and 4.5%, respectively, in the early-onset CAD group. There was no significant difference in the frequency of CC genotype and T allele carriers between early-onset CAD patients and controls. The frequency of the T allele was 22.3% in the control group and 21.1% in the early-onset CAD group. The T allele frequency of the variant was not significantly different between the two groups (P = 0.766), even after adjustments for age, gender, smoking status, hypertension, DM, and lipids were made. There was also no significant association between the genotype and the severity of CAD (P = 0.596). Furthermore, there was no correlation between the genotype and lipid levels or their ratios in both groups. The EL 584C/T gene polymorphism, therefore, was not associated with early-onset CAD or the severity of CAD in this Chinese Han population, suggesting that this variant is not always involved in the pathogenesis of early-onset CAD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tirosina / Doença da Artéria Coronariana / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Citosina / Lipase Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tirosina / Doença da Artéria Coronariana / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Citosina / Lipase Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China País de publicação: Brasil