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Regulation of zinc transporter 3 and carbonic anhydrases 2 and 14 mRNA expression in the retina of rats affected by low dietary zinc.
Zhang, P B; Xiao, H Y; Liu, H; Qin, R.
Afiliação
  • Zhang PB; First Affiliated Hospital of Nanjing Medical University, Maternal and Child Health Hospital of Jiangsu Province, Nanjing, Jiangsu Province, China peibinzhangcn@163.com.
  • Xiao HY; Maternal and Child Health Hospital of Changzhou, Nanjing, Jiangsu Province, China.
  • Liu H; First Affiliated Hospital of Nanjing Medical University, Maternal and Child Health Hospital of Jiangsu Province, Nanjing, Jiangsu Province, China.
  • Qin R; First Affiliated Hospital of Nanjing Medical University, Maternal and Child Health Hospital of Jiangsu Province, Nanjing, Jiangsu Province, China.
Genet Mol Res ; 13(1): 963-71, 2014 Feb 19.
Article em En | MEDLINE | ID: mdl-24634117
We looked at how zinc transporter 3 ZnT-3) mRNA expression in the rat retina is affected by low dietary zinc. Groups of 12 four-week-old male Sprague Dawley rats were fed on a low-zinc diet for 2, 4 or 6 weeks. Half of each group was then fed with a normal-zinc content diet and the other half was given a low-zinc content diet. The expression of ZnT-3, carbonic anhydrase 2 (CA2) and 14 (CA14) were detected by RT-PCR. After the rats were fed a low-zinc content diet for 2 weeks, their retina CA2 and CA14 mRNA levels were decreased, and the ZnT-3 mRNA was increased compared with the control rats. After they were fed a low-zinc diet for 4 weeks, ZnT-3, CA2 and CA14 mRNA levels decreased significantly. Then, after being changed back to a normal diet for 2 weeks, the rats had ZnT-3, CA2 and CA14 mRNA levels recovery in the retina.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Zinco / Anidrases Carbônicas / Proteínas de Transporte de Cátions Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Zinco / Anidrases Carbônicas / Proteínas de Transporte de Cátions Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China País de publicação: Brasil