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Evaluation of peri-implant mucosa: clinical, histopathological and immunological aspects.
de Araújo, Márcia Fernandes; Filho, Antonio Ferreira Leão; da Silva, Gabriela Pegorari; de Melo, Marcelo Luiz Ribeiro; Napimoga, Marcelo Henrique; Rodrigues, Denise Bertulucci Rocha; Alves, Polyanna Miranda; de Lima Pereira, Sanivia Aparecida.
Afiliação
  • de Araújo MF; Federal University of Triangulo Mineiro (UFTM), Brazil.
  • Filho AF; Laboratory of Biopathology and Molecular Biology, University of Uberaba (UNIUBE), Brazil.
  • da Silva GP; Laboratory of Biopathology and Molecular Biology, University of Uberaba (UNIUBE), Brazil.
  • de Melo ML; Laboratory of Biopathology and Molecular Biology, University of Uberaba (UNIUBE), Brazil.
  • Napimoga MH; Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Brazil.
  • Rodrigues DB; Laboratory of Biopathology and Molecular Biology, University of Uberaba (UNIUBE), Brazil; Cefores, Federal University of Triangulo Mineiro (UFTM), Brazil.
  • Alves PM; Cefores, Federal University of Triangulo Mineiro (UFTM), Brazil.
  • de Lima Pereira SA; Laboratory of Biopathology and Molecular Biology, University of Uberaba (UNIUBE), Brazil; Cefores, Federal University of Triangulo Mineiro (UFTM), Brazil. Electronic address: sanivia.pereira@uniube.br.
Arch Oral Biol ; 59(5): 470-8, 2014 May.
Article em En | MEDLINE | ID: mdl-24631629
OBJECTIVE: The aim was to compare the inflammatory response in peri-implant mucosa between patients with peri-implantitis (PP-group) and patients with healthy peri-implant tissues (HP-group). MATERIALS AND METHODS: Two fragments of peri-implant mucosa of 18 patients were collected and serial sections were performed for histological and immunohistochemical analysis. RESULTS: When compared with HP-group, PP-group showed higher immunostained cell density for TGF-ß, IL-17 and CD31, beyond greater density of red cells, leukocytes, mast cells chymase (MCC) and mast cell tryptase (MCT). HP-group patients showed higher IL-13 expression and increased amount of collagen fibres when compared with PP-group. In PP-group there was significant positive correlation between MCT density and density of blood vessels immunostained, and between MCC density and density of blood vessels immunostained. There was significant negative correlation between the IL-17 density and collagen percentage. CONCLUSIONS: This study demonstrated that in patients with peri-implantitis there was higher of TGF-ß and IL-17, indicating that these cytokines are directly involved in the inflammatory process. Thus, understanding the influence of cytokines in the peri-implantitis installation, new therapies could be developed in order to inhibit the synthesis of IL-17 and induce synthesis of IL-13 in peri-implant tissue, contributing to increase the longevity of the implant.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peri-Implantite Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Arch Oral Biol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peri-Implantite Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Arch Oral Biol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido