Your browser doesn't support javascript.
loading
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats.
Sousa, Dircilei Nascimento de; Santana, Washington Macedo de; Ferreira, Vania Moraes; Duarte, Wagner Rodrigues.
Afiliação
  • Sousa DN; Brasília University, Health Sciences Faculty, BrasíliaDF, Brazil, Fellow Master degree, Postgraduate Program in Health Sciences, Health Sciences Faculty, Brasília University (UNB), Brasília-DF, Brazil. Surgical procedures, acquisition and interpretation of data, manuscript writing.
  • Santana WM; UNB, Health Sciences Faculty, BrasíliaDF, Brazil, Fellow PhD degree, Postgraduate Program in Health Sciences, Health Sciences Faculty, UNB, Brasília-DF, Brazil. Surgical procedures, acquisition and interpretation of data, manuscript writing.
  • Ferreira VM; UNB, Health Sciences Faculty, BrasíliaDF, Brazil, PhD, Full Professor, Health Sciences Faculty, UNB, Brasília-DF, Brazil. Statistical analysis, English language, critical revision.
  • Duarte WR; UNB, Health Sciences Faculty, BrasíliaDF, Brazil, PhD, Full Professor, Health Sciences Faculty, UNB, Brasília-DF, Brazil. Conception and design of the study, manuscript writing.
Acta Cir Bras ; 29(3): 151-7, 2014 Mar.
Article em En | MEDLINE | ID: mdl-24626726
PURPOSE: To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae. METHODS: Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ceramic®) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery. RESULTS: The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats, except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action. CONCLUSION: Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Regeneração Óssea / Cognição / Sinvastatina / Anticolesterolemiantes Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Regeneração Óssea / Cognição / Sinvastatina / Anticolesterolemiantes Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil