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[Anti-Müllerian hormone serum levels in women with and without uterine fibroids]. / Concentraciones en suero de hormona antimülleriana en mujeres con y sin miomatosis uterina.
Ginecol Obstet Mex ; 81(12): 700-5, 2013 Dec.
Article em Es | MEDLINE | ID: mdl-24620523
BACKGROUND: The etiology of uterine leiomyomatosis is multifactorial and it is unknown if a relation between anti-Müllerian hormone (hormona anti-mülleriana) and uterine leiomyomatosis exists. OBJECTIVE: To determine the differences of hormona anti-mülleriana levels in women with and without uterine leiomyomatosis. METHODS: 60 women were studied (30 with and 30 without uterine leiomyomatosis). The diagnosis was confirmed by histopathology. Both groups were paired by age and in all them serum levels of hormona antimülleriana were measured using ELISA, also estradiol and progesterone serum levels were determined. hormona anti-mülleriana-RII immunohistochemistry was done in healthy myometrium and in leiomyomas. RESULTS: The mean age between the groups didn't show statistical difference (41.8 +/- 5.6 years vs. 41.4 +/- 5.7 years). Also no differences were found in weight, height and body mass index. Serum levels of hormona antimülleriana were lower in those with leiomyomatosis [0.21 (0-10.4) ng/ml vs. 1.83 (0-6.38) ng/ml, p < 0.005]. No statistical differences were found in estradiol and progesterone serum levels between the groups. The hormona antimülleriana receptor was no expressed neither in the healthy myometrium nor in the leiomyomas. CONCLUSIONS: Women with leiomyomatosis had lower hormona antimülleriana levels. More studies are needed to determine if a relation exists between hormona antimülleriana and uterine leiomyomas.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Hormônio Antimülleriano / Leiomioma Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Middle aged Idioma: Es Revista: Ginecol Obstet Mex Ano de publicação: 2013 Tipo de documento: Article País de publicação: México
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Hormônio Antimülleriano / Leiomioma Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Middle aged Idioma: Es Revista: Ginecol Obstet Mex Ano de publicação: 2013 Tipo de documento: Article País de publicação: México