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Modulatory activity of Brazilian red propolis on chemically induced dermal carcinogenesis.
Pinheiro, Kariny Souza; Ribeiro, Danielle Rodrigues; Alves, Angela Valéria Farias; Pereira-Filho, Rose Nely; Oliveira, Clauberto Rodrigues de; Lima, Sônia Oliveira; Reis, Francisco Prado; Cardoso, Juliana Cordeiro; Albuquerque-Júnior, Ricardo Luiz Cavalcanti de.
Afiliação
  • Pinheiro KS; Tiradentes University, AracajuSE, Brazil, Fellow Master degree, Postgraduate Program in Health and Environment, Tiradentes University (UNIT), Aracaju-SE, Brazil. Technical procedures, manuscript writing.
  • Ribeiro DR; UNIT, AracajuSE, Brazil, Fellow PhD degree, Postgraduate Program in Industrial Biotechnology, UNIT, Aracaju-SE, Brazil. Acquisition and interpretation of data, supervised all phases of the study.
  • Alves AV; UNIT, AracajuSE, Brazil, Fellow Master degree, Postgraduate Program in Health and Environment, UNIT, Aracaju-SE, Brazil. Histological processing of the surgical samples.
  • Pereira-Filho RN; UNIT, AracajuSE, Brazil, Fellow PhD degree, Postgraduate Program in Industrial Biotechnology, UNIT, Aracaju-SE, Brazil. Histological processing of the surgical samples.
  • Oliveira CR; UNIT, AracajuSE, Brazil, Fellow Master degree, Postgraduate Program in Biotechnology, UNIT, Aracaju-SE, Brazil. Chromatographic procedures, analysis of the chemical compounds of the red propolis extract.
  • Lima SO; UNIT, Department of Medicine, AracajuSE, Brazil, PhD, Full Professor, Department of Medicine, UNIT, Aracaju-SE, Brazil. Supervision of the surgical procedures in rodent model.
  • Reis FP; UNIT, Department of Medicine, AracajuSE, Brazil, PhD, Full Professor, Department of Medicine, UNIT, Aracaju-SE, Brazil. Supervision of the surgical procedures in rodent model.
  • Cardoso JC; UNIT, Department of Pharmacy, AracajuSE, Brazil, PhD, Full Professor, Laboratory of Biomaterials, Department of Pharmacy, UNIT, Aracaju-SE, Brazil. Statistical analysis, manuscript writing, critical revision.
  • Albuquerque-Júnior RL; UNIT, Department of Pharmacy, AracajuSE, Brazil, PhD, Full Professor, Laboratory of Biomaterials, Department of Pharmacy, UNIT, Aracaju-SE, Brazil. Statistical analysis, manuscript writing, critical revision.
Acta Cir Bras ; 29(2): 111-7, 2014 Feb.
Article em En | MEDLINE | ID: mdl-24604315
PURPOSE: To evaluate modulatory effects of a hydroalcoholic extract of Brazilian red propolis (HERP) on dermal carcinogenesis using a murine model. METHODS: The HERP was used at concentrations of 10, 50 and 100 mg/kg (PROP10, PROP50 and PROP100, respectively) to modulate dermal carcinogenesis induced by the application of 9,10-dimetil-1,2-benzatraceno (DMBA) on the backs of animals. RESULTS: The chemical compounds identified in HERP included propyl gallate, catechin, epicatechin and formononetin. PROP100 treatment resulted in significantly decreased tumor multiplicity throughout the five weeks of tumor promotion (p<0.05), and this concentration also resulted in the highest frequency of verrucous tumors (p<0.05). All of the tumors that developed in DMBA-treated animals were regarded as squamous cell carcinomas and were either diagnosed as non-invasive verrucous carcinomas or invasive squamous cell carcinomas (SCCs). The average score for malignancy was significantly lower in the PROP100-treated group than the non-treated group (p<0.05), but there was no difference between the other groups (p>0.05). CONCLUSION: The oral administration of hydroalcoholic extract of Brazilian red propolis at a dose of 100 mg/kg had a significant modulatory effect on the formation, differentiation and progression of chemically induced squamous cell carcinoma in a murine experimental model.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Neoplasias Cutâneas / Carcinoma de Células Escamosas / Antineoplásicos Fitogênicos Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Acta Cir Bras Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Neoplasias Cutâneas / Carcinoma de Células Escamosas / Antineoplásicos Fitogênicos Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Acta Cir Bras Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil