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Increased production of autoantibodies and specific antibodies in response to influenza virus vaccination in physically active older individuals.
Bachi, André L L; Suguri, Vinicius M; Ramos, Luiz Roberto; Mariano, Mario; Vaisberg, Mauro; Lopes, Jose D.
Afiliação
  • Bachi AL; Department of Microbiology and Immunology, Federal University of São Paulo, Brazil.
  • Suguri VM; Department of Otorhinolaryngology, Federal University of São Paulo, Brazil.
  • Ramos LR; Department of Preventive Medicine, Federal University of São Paulo, Brazil.
  • Mariano M; Department of Microbiology and Immunology, Federal University of São Paulo, Brazil.
  • Vaisberg M; Department of Otorhinolaryngology, Federal University of São Paulo, Brazil.
  • Lopes JD; Department of Microbiology and Immunology, Federal University of São Paulo, Brazil.
Results Immunol ; 3: 10-6, 2013.
Article em En | MEDLINE | ID: mdl-24600554
Immunosenescence is associated to aging and among many changes in immune response is reported a reduced response to vaccination and an increase in the number of cases of autoimmunity, caused by autoantibodies known as natural antibodies whose function, according to reports, would be protection against infection and inflammation. Although immunosenescence is an irreversible process, regular moderate exercise can attenuate some aspects of the decline in the immune system. So, the aim of this study was to investigate the humoral immune response in physically active elderly individuals before and 30 days after vaccination against influenza virus. The results showed that the percentage of individuals positive for antinuclear antibodies and serum immunoglobulin M and G levels after vaccination were higher in the group that exercised regularly than in the sedentary group. We were also able to demonstrate a significant correlation between levels of natural autoantibodies and response to vaccination.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Results Immunol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Results Immunol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda