Your browser doesn't support javascript.
loading
Association of Trypanosoma cruzi infection with risk factors and electrocardiographic abnormalities in northeast Mexico.
Molina-Garza, Zinnia Judith; Rosales-Encina, José Luis; Mercado-Hernández, Roberto; Molina-Garza, Daniel P; Gomez-Flores, Ricardo; Galaviz-Silva, Lucio.
Afiliação
  • Galaviz-Silva L; Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Ave, Universidad SN, Cd, Universitaria, San Nicolás de los Garza, Nuevo León 66451, México. lucio.galavizsl@uanl.edu.mx.
BMC Infect Dis ; 14: 117, 2014 Mar 01.
Article em En | MEDLINE | ID: mdl-24580840
BACKGROUND: American trypanosomiasis is a major disease and public health issue, caused by the protozoan parasite Trypanosoma cruzi. The prevalence of T. cruzi has not been fully documented, and there are few reports of this issue in Nuevo Leon. The aim of this study was to update the seroprevalence rate of T. cruzi infection, including an epidemiological analysis of the risk factors associated with this infection and an electrocardiographic (ECG) evaluation of those infected. METHODS: Sera from 2,688 individuals from 10 municipalities in the state of Nuevo Leon, Mexico, were evaluated using an enzyme-linked immunosorbent assay and an indirect hemagglutination assay. An ECG case-control study was performed in subjects seropositive for T. cruzi and the results were matched by sex and age to seronegative residents of the same localities. A univariate analysis with χ2 and Fisher's exact tests was used to determine the association between seropositivity and age (years), sex, and ECG changes. A multivariate analysis was then performed to calculate the odd ratios between T. cruzi seropositivity and the risk factors. RESULTS: The seropositive rate was 1.93% (52/2,688). In the ECG study, 22.85% (8/35) of the infected individuals exhibited ECG abnormalities. Triatoma gerstaeckeri was the only vector reported. The main risk factors were ceiling construction material (P ≤ 0.0024), domestic animals (P ≤ 0.0001), and living in rural municipalities (P ≤ 0.0025). CONCLUSIONS: These findings demonstrate a 10-fold higher prevalence of Chagas disease than previously reported (0.2%), which implies a serious public health threat in northeastern Mexico. The epidemiological profile established in this study differs from that found in the rest of Mexico, where human populations live in close proximity to domiciliary triatomines.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma cruzi / Doença de Chagas / Eletrocardiografia Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma cruzi / Doença de Chagas / Eletrocardiografia Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido