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Spectral Analysis of EEG in Familial Alzheimer's Disease with E280A Presenilin-1 Mutation Gene.
Rodriguez, Rene; Lopera, Francisco; Alvarez, Alfredo; Fernandez, Yuriem; Galan, Lidice; Quiroz, Yakeel; Bobes, Maria Antonieta.
Afiliação
  • Rodriguez R; Clinical Neurophysiology Department, Cuban Neuroscience Center, Havana, CP 10400, Cuba.
  • Lopera F; Antioquia University, Medellin, CP 1226, Colombia.
  • Alvarez A; Clinical Neurophysiology Department, Cuban Neuroscience Center, Havana, CP 10400, Cuba.
  • Fernandez Y; Cognitive Department, Cuban Neuroscience Center, Havana, CP 10400, Cuba.
  • Galan L; Cognitive Department, Cuban Neuroscience Center, Havana, CP 10400, Cuba.
  • Quiroz Y; Antioquia University, Medellin, CP 1226, Colombia.
  • Bobes MA; Cognitive Department, Cuban Neuroscience Center, Havana, CP 10400, Cuba.
Int J Alzheimers Dis ; 2014: 180741, 2014.
Article em En | MEDLINE | ID: mdl-24551475
To evaluate the hypothesis that quantitative EEG (qEEG) analysis is susceptible to detect early functional changes in familial Alzheimer's disease (AD) preclinical stages. Three groups of subjects were selected from five extended families with hereditary AD: a Probable AD group (18 subjects), an asymptomatic carrier (ACr) group (21 subjects), with the mutation but without any clinical symptoms of dementia, and a normal group of 18 healthy subjects. In order to reveal significant differences in the spectral parameter, the Mahalanobis distance (D (2)) was calculated between groups. To evaluate the diagnostic efficiency of this statistic D (2), the ROC models were used. The ROC curve was summarized by accuracy index and standard deviation. The D (2) using the parameters of the energy in the fast frequency bands shows accurate discrimination between normal and ACr groups (area ROC = 0.89) and between AD probable and ACr groups (area ROC = 0.91). This is more significant in temporal regions. Theses parameters could be affected before the onset of the disease, even when cognitive disturbance is not clinically evident. Spectral EEG parameter could be firstly used to evaluate subjects with E280A Presenilin-1 mutation without impairment in cognitive function.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Int J Alzheimers Dis Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Cuba País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Int J Alzheimers Dis Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Cuba País de publicação: Estados Unidos