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Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions.
Machado-Filho, João Ananias; Correia, Alyne Oliveira; Montenegro, Anyssa Brilhante Aires; Nobre, Maria Elizabeth Pereira; Cerqueira, Gilberto Santos; Neves, Kelly Rose Tavares; Naffah-Mazzacoratti, Maria da Graça; Cavalheiro, Esper Abrão; de Castro Brito, Gerly Anne; de Barros Viana, Glauce Socorro.
Afiliação
  • Machado-Filho JA; Faculty of Medicine Estácio of Juazeiro do Norte, Brazil.
  • Correia AO; Faculty of Medicine Estácio of Juazeiro do Norte, Brazil.
  • Montenegro AB; Faculty of Medicine Estácio of Juazeiro do Norte, Brazil.
  • Nobre ME; Faculty of Medicine Estácio of Juazeiro do Norte, Brazil.
  • Cerqueira GS; Faculty of Medicine of the Federal University of Ceará, Brazil.
  • Neves KR; Faculty of Medicine of the Federal University of Ceará, Brazil.
  • Naffah-Mazzacoratti Mda G; Department of Experimental Neurology of the Federal University of São Paulo, Brazil.
  • Cavalheiro EA; Department of Experimental Neurology of the Federal University of São Paulo, Brazil.
  • de Castro Brito GA; Faculty of Medicine of the Federal University of Ceará, Brazil.
  • de Barros Viana GS; Faculty of Medicine Estácio of Juazeiro do Norte, Brazil; Faculty of Medicine of the Federal University of Ceará, Brazil. Electronic address: gbviana@live.com.
Behav Brain Res ; 264: 116-25, 2014 May 01.
Article em En | MEDLINE | ID: mdl-24525422
Several lines of evidences have shown the inversion association between coffee consumption and Parkinson's disease (PD) development. Caffeine is a methylxanthine known as a non-selective inhibitor of A2A and A1 adenosine receptors in the brain and shown to be a neuroprotective drug. The objectives were to study caffeine effects in a unilateral 6-OHDA model of PD in rats. Male rats were divided into the following groups: sham-operated (SO), striatal 6-OHDA-lesioned and 6-OHDA-lesioned and treated for 2 weeks with caffeine (10 and 20mg/kg, p.o.). Then, animals were subjected to behavioral (open field and apomorphine-induced rotations), neurochemical (striatal determinations of DA and DOPAC), histological (cresyl violet staining) and immunohistochemical (TH, TNF-α, IL-1ß and HDAC) evaluations. The results showed that while the 6-OHDA group presented a decreased locomotor activity and a high number of apomorphine-induced rotations, these behaviors were partially blocked by caffeine. Caffeine itself increased DA contents and reversed the decrease in striatal DA observed in the 6-OHDA-lesioned group. Furthermore, it improved the hippocampal neuronal viability and significantly increased TH immunoreactivity in the striatum of the 6-OHDA-lesioned group. In addition, caffeine treatment also decreased the number of immunopositive cells for HDAC and pro-inflammatory cytokines TNF-α and IL-1ß. All these effects points out to a neuroprotective effect of caffeine and its potential benefit in the prevention and treatment of PD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Cafeína / Citocinas / Fármacos Neuroprotetores / Histona Desacetilases Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Cafeína / Citocinas / Fármacos Neuroprotetores / Histona Desacetilases Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda