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Effect of glucans from Caripia montagnei mushroom on TNBS-induced colitis.
Nascimento Santos, Marilia da S; de M Magalhães, Joedyson Emmanuel; Castro, Luiza Sheyla Evenni P Will; de Sousa Pinheiro, Thuane; Sabry, Diego Araujo; Nobre, Leonardo Thiago Duarte B; Lima, João Paulo Matos Santos; Baseia, Iuri Goulart; Leite, Edda Lisboa.
Afiliação
  • Nascimento Santos Mda S; Laboratory of Glycobiology, Department of Biochemistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 3000, Bairro L. Nova, CEP 59078-970, Natal, RN, Brazil. mariliabio84@gmail.com.
  • de M Magalhães JE; Laboratory of Glycobiology, Department of Biochemistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 3000, Bairro L. Nova, CEP 59078-970, Natal, RN, Brazil. joedyson_magalhaes@hotmail.com.
  • Castro LS; Laboratory of Glycobiology, Department of Biochemistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 3000, Bairro L. Nova, CEP 59078-970, Natal, RN, Brazil. lsepwill_@gmail.com.
  • de Sousa Pinheiro T; Laboratory of Glycobiology, Department of Biochemistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 3000, Bairro L. Nova, CEP 59078-970, Natal, RN, Brazil. tutu_sousa@hotmail.com.
  • Sabry DA; Department of Biochemistry, Federal University of Paraná, UFPR, Curitiba CEP 81531-980, PR, Brazil. popoh_diego@hotmail.com.
  • Nobre LT; Laboratory of Glycobiology, Department of Biochemistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 3000, Bairro L. Nova, CEP 59078-970, Natal, RN, Brazil. leo.dnobre@gmail.com.
  • Lima JP; Laboratory of Glycobiology, Department of Biochemistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 3000, Bairro L. Nova, CEP 59078-970, Natal, RN, Brazil. jplslima@gmail.com.
  • Baseia IG; Laboratory of Mycology, Department of Botany, Zoology and Ecology, Federal University of Rio Grande do Norte, Av. Salgado Filho, 3000, Bairro L. Nova 59078-970, Natal, RN, Brazil. baseia@cb.ufrn.br.
  • Leite EL; Laboratory of Glycobiology, Department of Biochemistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 3000, Bairro L. Nova, CEP 59078-970, Natal, RN, Brazil. eddaleite@cb.ufrn.br.
Int J Mol Sci ; 15(2): 2368-85, 2014 Feb 10.
Article em En | MEDLINE | ID: mdl-24518681
In this study, we evaluated the effect of different doses of polysaccharides extracted from Caripia montagnei mushroom at different intervals of treatment on colonic injury in the model of colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). The FT-IR analysis and NMR showed that the polysaccharides from this species of mushroom are composed of α- and ß-glucans. The colonic damage was evaluated by macroscopic, histological, biochemical and immunologic analyses. The results showed the reduction of colonic lesions in all groups treated with the glucans. Such glucans significantly reduced the levels of IL-6 (50 and 75 mg/kg, p < 0.05), a major inflammatory cytokine. Biochemical analyses showed that the glucans from C. montagnei acted on reducing levels of alkaline phosphatase (75 mg/kg, p < 0.01) and myeloperoxidase (p < 0.001), a result confirmed by the reduction of cellular infiltration observed microscopically. The increase of catalase activity possibly indicates a protective effect of these glucans on colonic tissue, confirming their anti-inflammatory potential.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite / Agaricales / Glucanos Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite / Agaricales / Glucanos Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça