Chemical composition of the essential oil of Lippia gracilis Schauer leaves and its potential as modulator of bacterial resistance.
Nat Prod Res
; 28(6): 399-402, 2014.
Article
em En
| MEDLINE
| ID: mdl-24479735
Lippia gracilis Schauer (Verbenaceae) is an aromatic plant widely used in folk medicine in the Brazilian semi-arid region. This work aims at evaluating the anti-microbial activity of essential oils from the leaves of L. gracilis (EOLG) when associated with commercial antibiotics against bacterial resistance. The essential oil obtained by hydrodistillation has 38 chemical constituents with thymol (44.4%), carvacrol (22.2%), p-cymene (6.2%) and α-pinene (5.6%) as major constituents. Microbiological assays were conducted by direct and gaseous contacts. We demonstrated that EOLG has significant synergism with all antibiotics tested. EOLG decreased the minimal inhibitory concentration of the aminoglycosides and improved their zone of inhibition more than 300% against Staphylococcus aureus and 270% against Pseudomonas aeruginosa. These results demonstrate that natural substances present in EOLG have the capacity to modulate bacterial resistance and can be used as an adjuvant therapy against multi-resistant microorganisms such as S. aureus, Escherichia coli and P. aeruginosa.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Óleos de Plantas
/
Óleos Voláteis
/
Lippia
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido