Clinical and serological evolution in chronic Chagas disease patients in a 4-year pharmacotherapy follow-up: a preliminary study.
Rev Soc Bras Med Trop
; 46(6): 776-8, 2013.
Article
em En
| MEDLINE
| ID: mdl-24474023
INTRODUCTION: The role of trypanocidal therapy in the chronic phase of Chagas disease remains controversial. METHODS: A total of 13 patients with chronic Chagas disease were treated with benznidazole (5mg/kg/day/60 days) and surveyed via antibody measurement and conventional electrocardiogram over the course of 4 years. RESULTS: The antibody titers were significantly reduced after 4 years (p<0.05). Most of the patients showed maintenance of the initial clinical picture (electrocardiographic), with the exception of 4 cases. CONCLUSIONS: Although trypanocidal therapy in the chronic phase of Chagas disease was of limited effectiveness, we believe that it is beneficial in treating these patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tripanossomicidas
/
Trypanosoma cruzi
/
Anticorpos Antiprotozoários
/
Doença de Chagas
/
Nitroimidazóis
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Rev Soc Bras Med Trop
Ano de publicação:
2013
Tipo de documento:
Article
País de publicação:
Brasil