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pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers.
Lima, Thamires Marques de; Kazama, Cristiane Mayumi; Koczulla, Andreas Rembert; Hiemstra, Pieter S; Macchione, Mariangela; Fernandes, Ana Luisa Godoy; Santos, Ubiratan de Paula; Bueno-Garcia, Maria Lucia; Zanetta, Dirce Maria; André, Carmen Diva Saldiva de; Saldiva, Paulo Hilario Nascimento; Nakagawa, Naomi Kondo.
Afiliação
  • Lima TM; Department of Pathology, Faculdade de Medicina, Universidade de São Paulo, São PauloSP, Brazil.
  • Kazama CM; Department of Pathology, Faculdade de Medicina, Universidade de São Paulo, São PauloSP, Brazil.
  • Koczulla AR; Department of Pulmonology, Philipps University, Marburg, Germany.
  • Hiemstra PS; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
  • Macchione M; Department of Pathology, Faculdade de Medicina, Universidade de São Paulo, São PauloSP, Brazil.
  • Fernandes AL; Department of Pneumology, School of Medicine, Universidade Federal de São Paulo, São PauloSP, Brazil.
  • Santos Ude P; Pneumology Division, Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São PauloSP, Brazil.
  • Bueno-Garcia ML; Department of Internal Medicine, Faculdade de Medicina, Universidade de São Paulo, São PauloSP, Brazil.
  • Zanetta DM; Department of Epidemiology, Public Health Faculty, Universidade de São Paulo, São PauloSP, Brazil.
  • André CD; Institute of Mathematics and Statistics, Universidade de São Paulo, São PauloSP, Brazil.
  • Saldiva PH; Department of Pathology, Faculdade de Medicina, Universidade de São Paulo, São PauloSP, Brazil.
  • Nakagawa NK; Department of Pathology, Faculdade de Medicina, Universidade de São Paulo, São PauloSP, Brazil.
Clinics (Sao Paulo) ; 68(12): 1488-94, 2013 Dec.
Article em En | MEDLINE | ID: mdl-24473505
OBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers related to air pollution. METHODS: A total of 87 male, non-smoking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in exhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study). RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values were lower in traffic-controllers (7.80 and 7.30, respectively). Both groups presented similar cytokines concentrations in both substrates, however, IL-1ß and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration was greater at the workplace of traffic-controllers compared with that of office-workers. CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Exposição Ocupacional / Expiração / Poluição do Ar / Lavagem Nasal Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Exposição Ocupacional / Expiração / Poluição do Ar / Lavagem Nasal Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos