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Patterns of care and outcomes in elderly patients with glioblastoma in Sao Paulo, Brazil: a retrospective study.
Pontes, Luciola de Barros; Loureiro, Luiz Victor Maia; Koch, Ludmila O; Karnakis, Theodora; Guendelmann, Rafael Aliosha Kaliks; Weltman, Eduardo; Malheiros, Suzana Maria Fleury.
Afiliação
  • Pontes Lde B; Department of Clinical Oncology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil. Electronic address: luciolapontes@yahoo.com.br.
  • Loureiro LV; Department of Clinical Oncology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Koch LO; Department of Clinical Oncology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Karnakis T; Department of Geriatrics Oncology, Hospital Israelita Albert Einstein and Universidade de Sao Paulo (USP/ICESP), Sao Paulo, Brazil.
  • Guendelmann RA; Department of Clinical Oncology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Weltman E; Department of Radiation Oncology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Malheiros SM; Department of Neuro-oncology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
J Geriatr Oncol ; 4(4): 388-93, 2013 Oct.
Article em En | MEDLINE | ID: mdl-24472484
OBJECTIVE: To analyze how elderly patients with glioblastoma are managed in Brazil. MATERIAL AND METHODS: We identified 30 patients aged ≥ 65 years treated between 2003 and 2011 at Albert Einstein Hospital in Sao Paulo. We retrospectively reviewed medical records to obtain data on clinical variables, treatment and outcomes. Overall survival (OS) was evaluated using Kaplan-Meier methods and compared using a Wilcoxon log-rank test. RESULTS: The median age was 73 years. The majority of patients (73.2%) underwent surgical intervention. Following surgery, 80% received radiotherapy (RT), and of those, 79.2% were treated with concurrent temozolomide (TMZ). The median progression free survival and OS were 5 and 10.6 months, respectively. Patients with a KPS ≥ 70 had a median OS of 16.2 months, compared to 6.4 months for those with a KPS <70 (p=0.032). For those patients in whom biopsy only was performed, the median OS was 5.3 months, as compared to 7.8 months for those who underwent partial resection and 18.6 months for those treated with gross total resection (p=0.021). A longer survival was found among patients who received RT versus those who did not (11 months vs. 1 month, p=0.003), as well as for those treated with chemoradiation (13.6 months vs. 6.4 months, p<0.0001). CONCLUSIONS: This study brings new information about the management of elderly patients with glioblastoma in Brazil. Our data may suggest that elderly patients who undergo cytoreductive surgery and adjuvant RT with concurrent TMZ can do better than those with less aggressive treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Geriatr Oncol Ano de publicação: 2013 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Geriatr Oncol Ano de publicação: 2013 Tipo de documento: Article País de publicação: Holanda