Interleukin-10 may protect against progressing injury during the acute phase of ischemic stroke.
Arq Neuropsiquiatr
; 71(11): 846-51, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24394869
UNLABELLED: Atherosclerosis is an inflammatory disease, and ischemic stroke is one of its most common and devastating manifestations. Proinflammatory cytokines play a key role in the progression of the irreversible ischemic lesions. The presence of anti-inflammatory mediators may prevent secondary ischemic injury. OBJECTIVES: 1) To assess the relationship between stroke severity and the serum levels of IL-1ß, IL-2, and IL-10; and 2) To analyze the neurological outcome after 72 h of ischemic stroke onset and expression of interleukins. METHOD: We measured the serum levels of IL-1ß, IL-2, and IL-10 in 26 patients with acute stroke. Neurological impairment was scored using the National Institute of Health Stroke Scale within the first 72 h after stroke onset. Thirty healthy subjects were analyzed as controls. RESULTS: Patients with IL-10 <925.0 pg/mL presented with neurological deterioration within the first 72 h. CONCLUSION: IL-10 may protect against ischemic injury during the acute phase of stroke.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose Intracraniana
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Isquemia Encefálica
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Interleucina-2
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Interleucina-10
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Acidente Vascular Cerebral
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Interleucina-1beta
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arq Neuropsiquiatr
Ano de publicação:
2013
Tipo de documento:
Article
País de publicação:
Alemanha