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Multifocal electroretinography after high dose chloroquine therapy for malaria.
de Carvalho, Aline Correa; Schwarz, Martin; Souza, Givago da Silva; Gomes, Bruno Duarte; Rosa, Alexandre Antônio Marques; Ventura, Ana Maria Revoredo da Silva; de Souza, José Maria; Silveira, Luiz Carlos de Lima; Kremers, Jan.
Afiliação
  • de Carvalho AC; Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Schwarz M; Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany.
  • Souza Gda S; Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brazil ; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Gomes BD; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Rosa AA; Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Ventura AM; Instituto Evandro Chagas, Belém, Pará, Brazil.
  • de Souza JM; Instituto Evandro Chagas, Belém, Pará, Brazil.
  • Silveira LC; Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brazil ; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Kremers J; Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany ; Rhenovia Pharma SAS, Mulhouse, France ; School of Life Sciences, University of Bradford, Bradford, UK.
J Ophthalmic Vis Res ; 8(3): 193-8, 2013 Jul.
Article em En | MEDLINE | ID: mdl-24349661
PURPOSE: To investigate changes in multifocal electroretinography (mfERG) parameters associated with high dose chloroquine therapy for treatment of malaria in the Amazonia region of Brazil. METHODS: Forty-eight subjects who had received chloroquine treatment for single or multiple malaria infections with a cumulative dose ranging from 1,050 to 27,000mg were included. The control group consisted of 37 healthy aged-matched subjects. Data was collected on amplitude and implicit time of the N1, P1 and N2 waves in the central macular hexagon (R1) and in five concentric rings at different retinal eccentricities (R2-R6). RESULTS: No significant difference was observed in any mfERG parameter between chloroquine treated patients and control subjects. A comparison with previous data obtained from patients with rheumatologic disorders in the same region of Brazil who had received larger cumulative doses of chloroquine and had displayed mfERG changes, indicated that retinal toxicity seems to be dependent on cumulative dose. CONCLUSION: Lack of mfERG changes in the current study suggests that intensive high dose chloroquine therapy for treatment of malaria is not associated with retinal toxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Ophthalmic Vis Res Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Ophthalmic Vis Res Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos