Effects of age on aerobic capacity in heart failure patients under beta-blocker therapy: possible impact in clinical decision-making?
Cardiol J
; 20(6): 655-61, 2013.
Article
em En
| MEDLINE
| ID: mdl-24338544
BACKGROUND: Heart failure (HF) is associated with impaired maximal aerobic capacity as indicated by decreases in peak oxygen uptake (peak VO(2)). Considering that aging by itself has a negative effect on this variable, the evaluation of maximum capacity is often questioned because current predicted peak VO(2) is based on subjects without heart disease or b-blocker therapy. In contrast, if decline in predicted and attained peak VO(2) were age-related, proportionally, loss of aerobic function (predicted peak VO(2), %) would remain stable over time in these patients. The purpose of this investigation is to assess the effects of age on peak VO(2) in HF patients taking b-blockers. METHODS: We retrospectively evaluated 483 (132 female) patients (aged 20-88 years, LVEF 31 ± 11%) with non-ischemic (n = 362), ischemic (n = 74) and Chagas-related HF (n = 47) who had been submitted to an incremental cardiopulmonary exercise testing on a motorized treadmill. Linear regression was used to develop the equation to predict peak VO(2), based on age. RESULTS: Peak VO(2) decreased 0.9 mL/min/kg per age-decade, maximum HR also decreased with aging and VE/VCO(2) slope was similar among all decades. The predicted new b-blocker equation to peak VO(2 bb) was 20.934 - 0.092 × age. CONCLUSIONS: Clinical interpretation of aerobic capacity impairment is influenced by aging in HF patients. This evidence must be considered when using peak VO(2) for prognostic stratification and clinical decision-making in patients with HF under b-blocker therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
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Técnicas de Apoio para a Decisão
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Tolerância ao Exercício
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Antagonistas Adrenérgicos beta
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Insuficiência Cardíaca
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cardiol J
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Polônia