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Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis activation.
França, Lucas Martins; Freitas, Larissa Nara Costa; Chagas, Vinicyus Teles; Coêlho, Caio Fernando Ferreira; Barroso, Wermerson Assunção; Costa, Graciomar Conceição; Silva, Lucilene Amorim; Debbas, Victor; Laurindo, Francisco Rafael Martins; Paes, Antonio Marcus de Andrade.
Afiliação
  • França LM; Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, Avenida dos Portugueses, 1966, 65.080-805 São Luís, MA, Brazil.
  • Freitas LN; Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, Avenida dos Portugueses, 1966, 65.080-805 São Luís, MA, Brazil.
  • Chagas VT; Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, Avenida dos Portugueses, 1966, 65.080-805 São Luís, MA, Brazil.
  • Coêlho CF; Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, Avenida dos Portugueses, 1966, 65.080-805 São Luís, MA, Brazil.
  • Barroso WA; Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, Avenida dos Portugueses, 1966, 65.080-805 São Luís, MA, Brazil.
  • Costa GC; Laboratory of Molecular and Cellular Pathology, Department of Pathology, Federal University of Maranhão, Avenida dos Portugueses, 1966, 65.080-805 São Luís, MA, Brazil.
  • Silva LA; Laboratory of Molecular and Cellular Pathology, Department of Pathology, Federal University of Maranhão, Avenida dos Portugueses, 1966, 65.080-805 São Luís, MA, Brazil.
  • Debbas V; Laboratory of Vascular Biology, Heart Institute, University of São Paulo, Avenida Enéas de Carvalho Aguiar, 44, 05.403-900 São Paulo, SP, Brazil.
  • Laurindo FR; Laboratory of Vascular Biology, Heart Institute, University of São Paulo, Avenida Enéas de Carvalho Aguiar, 44, 05.403-900 São Paulo, SP, Brazil.
  • Paes AM; Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão, Avenida dos Portugueses, 1966, 65.080-805 São Luís, MA, Brazil. Electronic address: marcuspaes@ufma.br.
Biochem Biophys Res Commun ; 443(2): 725-30, 2014 Jan 10.
Article em En | MEDLINE | ID: mdl-24333444
Non-alcoholic fatty liver disease (NAFLD) is intimately associated with insulin resistance and hypertriglyceridemia, whereas many of the mechanisms underlying this association are still poorly understood. In the present study, we investigated the relationship between microsomal triglyceride transfer protein (MTP) and markers of endoplasmic reticulum (ER) stress in the liver of rats subjected to neonatal monosodium L-glutamate (MSG)-induced obesity. At age 120 days old, the MSG-obese animals exhibited hyperglycemia, hypertriglyceridemia, insulin resistance, and liver steatosis, while the control (CTR) group did not. Analysis using fast protein liquid chromatography of the serum lipoproteins revealed that the triacylglycerol content of the very low-density lipoprotein (VLDL) particles was twice as high in the MSG animals compared with the CTR animals. The expression of ER stress markers, GRP76 and GRP94, was increased in the MSG rats, promoting a higher expression of X-box binding protein 1 (XBP-1), protein disulfide isomerase (PDI), and MTP. As the XBP-1/PDI/MTP axis has been suggested to represent a significant lipogenic mechanism in the liver response to ER stress, our data indicate that hypertriglyceridemia and liver steatosis occurring in the MSG rats are associated with increased MTP expression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Hipertrigliceridemia / Proteínas de Transporte / Isomerases de Dissulfetos de Proteínas / Proteínas de Ligação a DNA / Retículo Endoplasmático / Fígado Gorduroso Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Hipertrigliceridemia / Proteínas de Transporte / Isomerases de Dissulfetos de Proteínas / Proteínas de Ligação a DNA / Retículo Endoplasmático / Fígado Gorduroso Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos