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Transient increase in IL-1ß, IL-6 and TNF-α gene expression in rat liver exposed to gold nanoparticles.
Khan, H A; Abdelhalim, M A K; Alhomida, A S; Al Ayed, M S.
Afiliação
  • Khan HA; Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia khan_haseeb@yahoo.com.
Genet Mol Res ; 12(4): 5851-7, 2013 Nov 22.
Article em En | MEDLINE | ID: mdl-24301954
Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is controversial. We studied the acute (1 day) and sub-chronic (5 days) effects of gold nanoparticles (10 and 50 nm in diameter) on expression of interleukin-1 beta (IL-1ß), IL-6 and tumor necrosis factor alpha (TNF-α) in rat liver. Real-time PCR analysis showed that gold nanoparticles of both sizes significantly increased cytokine gene expression on day 1; this had subsided by day 5. The 50-nm gold nanoparticle produced more severe inflammation than the smaller gold nanoparticle. These findings indicate a possible biocompatibility of medium-sized gold nanoparticles, as they caused only a transient increase in proinflammatory cytokines, followed by normalization during sub-chronic repeated exposure.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Fator de Necrose Tumoral alfa / Interleucina-1beta / Nanopartículas Metálicas / Fígado Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Arábia Saudita País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Fator de Necrose Tumoral alfa / Interleucina-1beta / Nanopartículas Metálicas / Fígado Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Arábia Saudita País de publicação: Brasil