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Attenuation of adjuvant-induced arthritis in rats by phonophoresis with an aqueous gel of the Amazonian plant Elaeoluma nuda (Sapotaceae).
Merini, Lilian Regiani; Furtado, Silvânia da Conceição; de Oliveira, Marcelo Miguel Brito; Carneiro, Ana Lúcia Basílio; Boechat, Antonio Luiz; Barcellos, José Fernando Marques.
Afiliação
  • Merini LR; Postgraduate Program in Basic and Applied Immunology, Institute of Biological Sciences, Federal University of Amazonas, Brazil; Amazonian Group for the Study of Inflammation and Autoimmunity (GAIA), Brazil; Médio Solimões Institute of Health and Biotechnology, Coari Campus, Federal University of Ama
  • Furtado Sda C; Morphology Department, Institute of Biological Sciences, Federal University of Amazonas, Brazil; Amazonian Group for the Study of Inflammation and Autoimmunity (GAIA), Brazil.
  • de Oliveira MM; Undergraduate Science Project, Morphology Department, Institute of Biological Sciences, Federal University of Amazonas, Brazil.
  • Carneiro AL; Morphology Department, Center for Health Sciences, Federal University of Paraíba, Brazil.
  • Boechat AL; Postgraduate Program in Basic and Applied Immunology, Institute of Biological Sciences, Federal University of Amazonas, Brazil; Amazonian Group for the Study of Inflammation and Autoimmunity (GAIA), Brazil. Electronic address: antonioluiz.boechat@gmail.com.
  • Barcellos JF; Postgraduate Program in Basic and Applied Immunology, Institute of Biological Sciences, Federal University of Amazonas, Brazil; Morphology Department, Institute of Biological Sciences, Federal University of Amazonas, Brazil.
Cytokine ; 65(2): 231-5, 2014 Feb.
Article em En | MEDLINE | ID: mdl-24280124
BACKGROUND: Various species of the genus Pouteria (Elaeoluma) are used by the native population of Brazil because of, among other factors, their anti-inflammatory properties. The anti-inflammatory properties of the extract of the Amazonian plant Elaeoluma nuda were recently identified in prospective pharmacological studies. OBJECTIVES: The objective of this study was to assess the anti-inflammatory effect of phonophoresis with aqueous gel extract of E. nuda in rat adjuvant-induced arthritis. METHODOLOGY: Arthritis was induced in Lewis rats with an adjuvant. Phonophoresis with E. nuda gel was then administered daily and the results compared with those obtained with phonophoresis of diclofenac diethylammonium gel and ultrasound therapy without phonophoresis. Arthritis in the different groups was evaluated by plethysmometry. Proinflammatory cytokines TNF-α and IL-1α were quantified by cytometric bead array (CBA). RESULTS: The effect of phonophoresis of aqueous gel with E. nuda extract on arthritis in rats' paws (a 33% reduction compared with the controls) was the same as that produced by phonophoresis with diclofenac diethylammonium. Ultrasound therapy without phonophoresis produced no significant effect on the 21st day of therapy. There was a significant reduction in TNF-α and IL-1α levels in the group treated with phonophoresis with E. nuda gel (p=0.0042; p=0.0003, respectively). CONCLUSION: Our results demonstrate the anti-inflammatory effect of phonophoresis with E. nuda gel on cytokines TNF-α, IL-1α and adjuvant-induced arthritis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Água / Extratos Vegetais / Fonoforese / Sapotaceae / Géis Tipo de estudo: Prognostic_studies Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Cytokine Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Água / Extratos Vegetais / Fonoforese / Sapotaceae / Géis Tipo de estudo: Prognostic_studies Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Cytokine Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido