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Human herpesvirus-6 and cytomegalovirus DNA in liver donor biopsies and their correlation with HLA matches and acute cellular rejection.
Guardia, Ana Carolina; Stucchi, Raquel Silveira Bello; Milan, Arlete; Costa, Sandra Cecília Botelho; Boin, Ilka de Fátima Santana Ferreira.
Afiliação
  • Guardia AC; Faculty of Medical Science, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: carolguardia@yahoo.com.br.
  • Stucchi RS; Unit of Liver Transplantation, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: stucchi.raquel@gmail.com.
  • Milan A; Faculty of Medical Science, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: arletemilan@ig.com.br.
  • Costa SC; Internal Medicine Department, Diagnosis of Molecular Infection Disease, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: costa@fcm.unicamp.br.
  • Boin Ide F; Unit of Liver Transplantation, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: ilkaboin@yahoo.com.
Braz J Infect Dis ; 18(2): 220-4, 2014.
Article em En | MEDLINE | ID: mdl-24275367
UNLABELLED: Herpesvirus reactivation is common after liver transplantation. OBJECTIVE: Analyze the presence of cytomegalovirus (HCMV) and human herpesvirus-6 (HHV-6) DNA in liver donor biopsies, seeking to better understand issues involving human donor leukocyte antigens (HLA)-A, B and DR, as well as correlations with acute cellular rejection. METHODS: Fifty-nine liver transplantation patients were investigated for the presence of HCMV and HHV-6 DNA in liver donor biopsies, using the Nested-PCR technique. The clinical donor information and HLA matches were obtained from the São Paulo State Transplant System. The recipients' records regarding acute cellular rejection were studied. RESULTS: Seven (11.8%) biopsies were positive for HCMV DNA and 29 (49%) were positive for HHV-6 DNA. In 14 donors with HLA-DR 15 nine had HHV-6 DNA positive liver biopsy with a tendency for significant association (p=0.09), 22 recipients developed acute cellular rejection and 9/22 were positive for HLA-DR 15 (p=0.03; χ(2)=4.51), which was statistically significant in univariate analysis and showed a tendency after multivariate analysis (p=0.08). CONCLUSION: HHV-6 DNA was prevalent in liver donors studied as well as HLA-DR 15. These findings suggest that patients with HLA-DR 15 in liver donor biopsies develop more rejection after liver transplantation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA-DR / Transplante de Fígado / Herpesvirus Humano 6 / Infecções por Citomegalovirus / Infecções por Roseolovirus / Citomegalovirus / Rejeição de Enxerto / Fígado Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA-DR / Transplante de Fígado / Herpesvirus Humano 6 / Infecções por Citomegalovirus / Infecções por Roseolovirus / Citomegalovirus / Rejeição de Enxerto / Fígado Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil