Programmed hepatocytes cell death associated with FLIP downregulation in response to extracellular preS1/2.
J Med Virol
; 86(3): 496-504, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24248906
Chronic hepatitis B virus (HBV) infection involves liver damage resulting in continuous cell injury and death. During HBV infection, hepatocytes exhibit changes in death receptor expression and in their susceptibility to death. These changes are observed not only in infected cells but also in bystander cells. Because excess viral surface protein (HBsAg) is secreted in large amounts as soluble particles containing preS proteins, the role of soluble preS1/2 in hepatocyte (HepG2) death modulation is an important issue to be explored. An increase of cell death induced by preS1/2 was observed. Also, cell death was associated with the down-regulation of FLIP and activation of caspase 8, caspase 9, and BID. Additionally, hepatocytes exhibited a sensitization to death mediated by the Fas receptor. These results, may contribute to understanding the role of envelope proteins (preS1/2) in the pathogenesis of HBV infection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Hepatite B
/
Apoptose
/
Hepatócitos
/
Proteína Reguladora de Apoptosis Semelhante a CASP8 e FADD
/
Interações Hospedeiro-Patógeno
/
Antígenos de Superfície da Hepatite B
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Estados Unidos