Red blood cells derived from peripheral blood and bone marrow CD34⺠human haematopoietic stem cells are permissive to Plasmodium parasites infection.
Mem Inst Oswaldo Cruz
; 108(6): 801-3, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-24037205
The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax. Here, we demonstrated that CD34⺠hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum parasites.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Células-Tronco Hematopoéticas
/
Malária Vivax
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Antígenos CD34
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Eritrócitos
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Malária
Limite:
Humans
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
Brasil