Antimicrobial activity of meta-alkoxyphenylcarbamates containing substituted N-phenylpiperazine fragment.
Braz J Microbiol
; 43(3): 959-65, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-24031913
In the present investigation, the basic esters of meta-alkoxyphenylcarbamic acid bearing variously substituted N-phenylpiperazine fragment were screened for their in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans, respectively. The most effective against Escherichia coli was found the compound 6d (MIC=195,3 µg/mL) bearing simultaneously para-fluoro substituent at the 4-phenylpiperazin-1-yl core and meta-methoxy side chain in the lipophilic part of the molecule. From whole analyzed set of the molecules the substance 8e with propoxy side chain forming meta-alkoxyphenylcarbamoyl fragment and lipophilic, sterically bulky meta-trifluoromethyl group attached at N-phenylpiperazine moiety was evaluated as the most active against Candida albicans (MIC=97,7 µg/mL). On the contrary, all investigated structures were practically inactive against Staphylococcus aureus (MIC>1000 µg/mL).
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Braz J Microbiol
Ano de publicação:
2012
Tipo de documento:
Article
País de publicação:
Brasil