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No association of IFNG+874T/A SNP and NOS2A-954G/C SNP variants with nitric oxide radical serum levels or susceptibility to tuberculosis in a Brazilian population subset.
Leandro, Ana Cristina C S; Rocha, Márcia Andrade; Lamoglia-Souza, Andreia; VandeBerg, John L; Rolla, Valeria Cavalcanti; Bonecini-Almeida, Maria da Gloria.
Afiliação
  • Leandro AC; Immunology and Immunogenetics Laboratory, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Avenida Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, Brazil ; Department of Genetics and Southwest National Primate Research Center, Texas Biomedical Research Institute, 7620 NW Loop 410, 78227-5301 San Antonio, TX, USA.
Biomed Res Int ; 2013: 901740, 2013.
Article em En | MEDLINE | ID: mdl-24024215
Tuberculosis (TB) is one of the most common infectious diseases in the world. Mycobacterium tuberculosis infection leads to pulmonary active disease in approximately 5-10% of exposed individuals. Both bacteria- and host-related characteristics influence latent infection and disease. Host genetic predisposition to develop TB may involve multiple genes and their polymorphisms. It was reported previously that interferon gamma (IFN-γ) and nitric oxide synthase 2 (NOS2) are expressed on alveolar macrophages from TB patients and are responsible for bacilli control; thus, we aimed this study at genotyping single nucleotide polymorphisms IFNG+874T/A SNP and NOS2A-954G/C SNP to estimate their role on TB susceptibility and determine whether these polymorphisms influence serum nitrite and NOx(-) production. This case-control study enrolled 172 TB patients and 179 healthy controls. Neither polymorphism was associated with susceptibility to TB. NOS2A-954G/C SNP was not associated with serum levels of nitrite and NOx(-). These results indicate that variants of IFNG+874T/A SNP and NOS2A-954G/C SNP do not influence TB susceptibility or the secretion of nitric oxide radicals in the study population.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Interferon gama / Estudos de Associação Genética / Óxido Nítrico Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Biomed Res Int Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Interferon gama / Estudos de Associação Genética / Óxido Nítrico Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Biomed Res Int Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos