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Gingival overgrowth in renal transplant subjects: a 44-month follow-up study.
Costa, Lidiane C M; Costa, Fernando Oliveira; Cortelli, Sheila C; Cortelli, José R; Cota, Luís O M.
Afiliação
  • Costa LC; 1 Department of Periodontology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil. 2 Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil. 3 Address correspondence to: Fernando Oliveira Costa, B.D.S., M.Sc., Ph.D., Associate Professor, Department of Periodontology, School of Dentistry, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Pampulha, P.O. Box 359, Belo Horizonte, MG, Brazil 31270-901.
Transplantation ; 96(10): 890-6, 2013 Nov 27.
Article em En | MEDLINE | ID: mdl-23903015
BACKGROUND: To assess changes in gingival status of renal transplant subjects under immunosuppressive regimens based on cyclosporine (CsA), tacrolimus (Tcr), and sirolimus (Sir). METHODS: From a sample of 135 subjects (baseline examination [BE]), 89 without periodontal treatment, who maintained the immunosuppressive regimen based on the same main agent (CsA=23, Tcr=31, and Sir=35), were reexamined after 44 months (follow-up examination [FE]). Demographic, pharmacologic, and periodontal variables were collected and gingival overgrowth (GO) was assessed by visual examination. RESULTS: In Tcr and CsA groups, although not significant, occurrence of GO decreased (CsA [BE=56.5% and FE=34.8%; P=0.063] and Tcr [BE=19.4% and FE=12.9%; P=0.500]). In addition, the severity of GO decreased significantly in CsA group (mean score BE=10.29 ± 7.70 and mean score FE=0.78 ± 1.38; P=0.003). In Sir group, GO decreased from 17.1% (BE) to 0.0% (FE) (P=not applicable). In total sample, GO was associated with papillary bleeding index (P=0.001) and concomitant use of calcium channel blockers (P=0.029); in CsA and Tcr groups, GO was associated with papillary bleeding index (P=0.029 and 0.033, respectively). CONCLUSIONS: There was no incidence of GO, and a decrease in the occurrence and severity of GO was significant in total sample. This decrease can be attributed to changes in pharmacologic and periodontal variables over this period of time.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Crescimento Excessivo da Gengiva / Rejeição de Enxerto / Imunossupressores Tipo de estudo: Diagnostic_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Transplantation Ano de publicação: 2013 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Crescimento Excessivo da Gengiva / Rejeição de Enxerto / Imunossupressores Tipo de estudo: Diagnostic_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Transplantation Ano de publicação: 2013 Tipo de documento: Article País de publicação: Estados Unidos