[Presence of a non-HLA antigen in B-lymphocytes from patients with rheumatic fever and their relatives defined using monoclonal antibodies]. / Presencia de un antígeno no-HLA en los linfocitos B de pacientes con fiebre reumática y sus familiares definido mediante anticuerpos monoclonales.
Bol Med Hosp Infant Mex
; 47(5): 313-7, 1990 May.
Article
em Es
| MEDLINE
| ID: mdl-2390184
Numerous investigators have suspected that there is a genetic predisposition to rheumatic fever (RF). In this context a group of investigators at Rockefeller University have produced a monoclonal antibody that identifies an antigen present in 100% of all RF studied at that center. Using this antibody, labeled D8/17, we studied 47 patients with acute rheumatic fever and rheumatic heart disease. Of these, 39 were not receiving steroids at the of the test and 35 were positive for the marker (89.7%). The highest percentage of positive cells was seen in the probands with 34.6 +/- 13.16%, while unaffected mothers, fathers and siblings gave 24.9, 5.2 and 7.3% respectively. The control group had an average of 7.5% of positive cells. This study and previous ones, performed by the Rockefeller University group in which HLA typing was included, suggest an autosomal recessive mode of inheritance, not associated with the MHC system, for the D8/17 antigen. Rheumatic fever; non-HLA antigen in; genetic predisposition in.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cardiopatia Reumática
/
Linfócitos B
/
Antígenos HLA
/
Anticorpos Monoclonais
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
/
Humans
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Male
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Newborn
Idioma:
Es
Revista:
Bol Med Hosp Infant Mex
Ano de publicação:
1990
Tipo de documento:
Article
País de publicação:
México