Modulation of thyroid hormone receptors, TRα and TRß, by using different doses of triiodothyronine (T3) at different times.
Arq Bras Endocrinol Metabol
; 57(5): 368-74, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23896803
OBJECTIVE: To examine the effect of different doses of triiodothyronine (T3) on mRNA levels of thyroid hormone receptors, TRα and TRß, at different times. MATERIALS AND METHODS: 3T3-L1 adipocytes were incubated with T3 (physiological dose: F; supraphysiological doses: SI or SII), or without T3 (control, C) for 0.5, 1, 6, or 24h. TRα and TRß mRNA was detected using real-time polymerase chain reaction. RESULTS: F increased TRß mRNA levels at 0.5h. After 1h, TRα levels increased with F and SI and TRß levels decreased with SII compared with C, F, and SI. After 6h, both genes were suppressed at all concentrations. In 24h, TRα and TRß levels were similar to those of C group. CONCLUSIONS: T3 action with F began at 1h for TRα and at 0.5h for TRß. These results suggest the importance of knowing the times and doses that activate T3 receptors in adipocytes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tri-Iodotironina
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Modulação Antigênica
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Adipócitos
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Receptores alfa dos Hormônios Tireóideos
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Receptores beta dos Hormônios Tireóideos
Limite:
Animals
Idioma:
En
Revista:
Arq Bras Endocrinol Metabol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil