Mild diabetes models and their maternal-fetal repercussions.
J Diabetes Res
; 2013: 473575, 2013.
Article
em En
| MEDLINE
| ID: mdl-23878822
The presence of diabetes in pregnancy leads to hormonal and metabolic changes making inappropriate intrauterine environment, favoring the onset of maternal and fetal complications. Human studies that explore mechanisms responsible for changes caused by diabetes are limited not only for ethical reasons but also by the many uncontrollable variables. Thus, there is a need to develop appropriate experimental models. The diabetes induced in laboratory animals can be performed by different methods depending on dose, route of administration, and the strain and age of animal used. Many of these studies are carried out in neonatal period or during pregnancy, but the results presented are controversial. So this paper, addresses the review about the different models of mild diabetes induction using streptozotocin in pregnant rats and their repercussions on the maternal and fetal organisms to propose an adequate model for each approached issue.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gravidez em Diabéticas
/
Diabetes Gestacional
/
Diabetes Mellitus Experimental
/
Modelos Animais de Doenças
Tipo de estudo:
Prognostic_studies
Aspecto:
Ethics
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Diabetes Res
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido