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Effects of deformation on transmural dispersion of repolarization using in silico models of human left ventricular wedge.
de Oliveira, B L; Rocha, B M; Barra, L P S; Toledo, E M; Sundnes, J; Weber dos Santos, R.
Afiliação
  • de Oliveira BL; Simula Research Laboratory, Lysaker, Norway; Graduate Program in Computational Modeling of the Federal University of Juiz de Fora, Brazil.
Int J Numer Method Biomed Eng ; 29(12): 1323-37, 2013 Dec.
Article em En | MEDLINE | ID: mdl-23794390
Mechanical deformation affects the electrical activity of the heart through multiple feedback loops. The purpose of this work is to study the effect of deformation on transmural dispersion of repolarization and on surface electrograms using an in silico human ventricular wedge. To achieve this purpose, we developed a strongly coupled electromechanical cell model by coupling a human left ventricle electrophysiology model and an active contraction model reparameterized for human cells. This model was then embedded in tissue simulations on the basis of bidomain equations and nonlinear solid mechanics. The coupled model was used to evaluate effects of mechanical deformation on important features of repolarization and electrograms. Our results indicate an increase in the T-wave amplitude of the surface electrograms in simulations that account for the effects of cardiac deformation. This increased T-wave amplitude can be explained by changes to the coupling between neighboring myocytes, also known as electrotonic effect. The thickening of the ventricular wall during repolarization contributes to the decoupling of cells in the transmural direction, enhancing action potential heterogeneity and increasing both transmural repolarization dispersion and T-wave amplitude of surface electrograms. The simulations suggest that a considerable percentage of the T-wave amplitude (15%) may be related to cardiac deformation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Função Ventricular / Sistema de Condução Cardíaco / Modelos Cardiovasculares Limite: Humans Idioma: En Revista: Int J Numer Method Biomed Eng Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Função Ventricular / Sistema de Condução Cardíaco / Modelos Cardiovasculares Limite: Humans Idioma: En Revista: Int J Numer Method Biomed Eng Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido