Bradykinin facilitates the purinergic motor component of the rat bladder neurotransmission.
Neurosci Lett
; 113(2): 227-32, 1990 May 31.
Article
em En
| MEDLINE
| ID: mdl-2377320
The motor activity of the rat bladder elicited by transmural electrical stimulation was abolished in the presence of 200 nM tetrodotoxin but not of 1 microM atropine plus 3.4 microM guanethidine. Tissue preincubation with 20 microM, alpha, beta-methylene ATP reduced but did not obliterate the electrically-induced motor effect. Bradykinin (BK) caused a short-lasting motor response while it potentiated, in a concentration-dependent fashion, the 0.15-5 Hz-induced muscle twitching. The facilitatory action of the peptide lasted for at least 5 min and was blocked by the BK-B2 receptor antagonist D-Arg0 [Hyp3, Thi5,8, D-Phe7]-BK. The motor response caused by the exogenous application of adenosine 5'-triphosphate (ATP) was almost immediate and lasted less than 30 s; it was also potentiated by BK-B2 receptor activation, an effect that was reduced in a concentration-dependent manner by pretreatment with the BK-receptor antagonist.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Bexiga Urinária
/
Bradicinina
/
Trifosfato de Adenosina
/
Neurônios Motores
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Irlanda