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The relationship between nutritional status, vitamin A and zinc levels and oxidative stress in patients with ataxia-telangiectasia.
da Silva, R; dos Santos-Valente, E C; Burim Scomparini, F; Saccardo Sarni, R O; Costa-Carvalho, B T.
Afiliação
  • da Silva R; Federal University of Sao Paulo, Sao Paulo, SP, Brazil; Federal University of Alfenas, Alfenas, MG, Brazil.
  • dos Santos-Valente EC; Federal University of Sao Paulo, Sao Paulo, SP, Brazil.
  • Burim Scomparini F; Federal University of Sao Paulo, Sao Paulo, SP, Brazil.
  • Saccardo Sarni RO; Federal University of Sao Paulo, Sao Paulo, SP, Brazil; ABC University, Santo Andre, SP, Brazil.
  • Costa-Carvalho BT; Federal University of Sao Paulo, Sao Paulo, SP, Brazil. Electronic address: beacarvalho@terra.com.br.
Allergol Immunopathol (Madr) ; 42(4): 329-35, 2014.
Article em En | MEDLINE | ID: mdl-23769738
BACKGROUND: Ataxia-telangiectasia (A-T) is a rare and degenerative disease that leads to varying degrees of immunodeficiency, oxidative stress, and malnutrition. Vitamin A and zinc are essential for immune function and antioxidant defence. OBJECTIVE: To compare levels of retinol, beta carotene, and zinc in patients with ataxia-telangiectasia and healthy controls. METHODS: We performed a cross-sectional study with 14 AT patients and 14 healthy controls matched for age and gender. All participants underwent a nutritional and laboratory evaluation comprising concentrations of retinol, beta carotene, serum and erythrocyte zinc, malondialdehyde (MDA), T lymphocyte numbers (CD4(+) and CD8(+)) and immunoglobulin (IgA). RESULTS: The AT patients showed high rates of malnutrition with reduced lean body mass when compared to the control group. However, the concentrations of MDA, retinol, beta carotene, and serum and erythrocyte zinc in AT patients were similar to those of the control group. The retinol levels presented a negative correlation with MDA and positive correlation with IgA serum level. CONCLUSIONS: The AT patients assessed showed no change in nutritional status for vitamin A and zinc; however, they presented severe impairment in overall nutritional status observed and correlation between retinol with MDA and IgA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina A / Zinco / Ataxia Telangiectasia / Estado Nutricional / Estresse Oxidativo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Allergol Immunopathol (Madr) Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Singapura
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina A / Zinco / Ataxia Telangiectasia / Estado Nutricional / Estresse Oxidativo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Allergol Immunopathol (Madr) Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Singapura