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In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative.
Lucarini, Rodrigo; Bernardes, Wagner A; Ferreira, Daniele S; Tozatti, Marcos G; Furtado, Ricardo; Bastos, Jairo K; Pauletti, Patrícia M; Januário, Ana H; Silva, Márcio L Andrade E; Cunha, Wilson R.
Afiliação
  • Lucarini R; Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil.
Pharm Biol ; 51(9): 1087-90, 2013 Sep.
Article em En | MEDLINE | ID: mdl-23738822
CONTEXT: Despite several pharmacological applications of Rosmarinus officinalis L. (Lamiaceae), studies on its analgesic and anti-inflammatory properties have been scarce. OBJECTIVE: The aim of this work was to use in vivo models to evaluate the analgesic and anti-inflammatory activities of the aqueous extracts obtained from leaves (AEL) and stems (AES) of Rosmarinus officinalis, as well as its isolated compound--rosmarinic acid (RA). We also prepared and assessed the acetyl ester derivative of RA. MATERIALS AND METHODS: The analgesic activity was evaluated using abdominal constriction and formalin tests. For the evaluation of the anti-inflammatory effects, carrageenin-induced paw edema in rats were used. The extracts were used at doses of 100, 200 and 400 mg kg⁻¹ compounds were tested at 10, 20 and 40 mg kg⁻¹. RESULTS: Orally administered AEL, AES and RA were not significantly active at any of the doses tested during the abdominal constriction test; the acetyl ester derivative of RA displayed significant analgesic activity. In the carrageenin-induced paw edema assay, the acetyl derivative of RA at all the tested doses produced significant anti-inflammatory effects and reduced the number of paw licks in the second phase of the formalin test. DISCUSSION AND CONCLUSION: The results suggest that the analgesic effects of the acetyl derivative of RA operate via a peripheral-mediated mechanism. The acetyl ester derivative of RA is potentially applicable as a new lead compound for the management of pain and inflammation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Anti-Inflamatórios não Esteroides / Cinamatos / Inflamação Neurogênica / Rosmarinus / Modelos Animais de Doenças / Depsídeos / Neuralgia Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Pharm Biol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Anti-Inflamatórios não Esteroides / Cinamatos / Inflamação Neurogênica / Rosmarinus / Modelos Animais de Doenças / Depsídeos / Neuralgia Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Pharm Biol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido