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Antioxidant, anti-inflammatory, and hypoglycemic effects of the leaf extract from Passiflora nitida Kunth.
Montefusco-Pereira, Carlos Victor; de Carvalho, Maria José; de Araújo Boleti, Ana Paula; Teixeira, Lorisa Simas; Matos, Humberto Reis; Lima, Emerson Silva.
Afiliação
  • Montefusco-Pereira CV; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Amazonas Federal University, Alexandre Amorim Street, 330, 69010-300 Aparecida, Manaus, Amazonas, Brazil.
Appl Biochem Biotechnol ; 170(6): 1367-78, 2013 Jul.
Article em En | MEDLINE | ID: mdl-23666642
Diabetes mellitus is a metabolic disease characterized by abnormally high plasma glucose levels, leading to major complications, such as insulin resistance, obesity, hyperlipidemia, and hypertension, also with alterations in the immune and neuronal systems. Brazilian plants have been studied as important sources for new molecules with medicinal properties. The genus Passiflora known as "Maracujá" has been used as a traditional folk medicine for a long time, so an investigation was performed regarding an endemic kind of passion fruit (Passiflora nitida Kunth) from Amazonas, Brazil. Here, we aimed to determine its potential biological activity against metabolic syndrome, oxidative stress, pain, and inflammation. The hydroethanol leaf extract revealed an in vitro α-glucosidase inhibitory activity of 50 % inhibitory concentration (IC50) = 6.78 ± 0.31 µg/mL and an α-amylase inhibition of IC50= 93.36 ± 4.37. In vivo, experiments of different saccharide tolerance resulted in significant glycemia control and, with alloxan-diabetic mice, resulted in a decrease of total cholesterol, a hypoglycemic effect, and an antioxidant activity by thiobarbituric acid-reactive substances measurement. Also, it decreased the carrageenan-induced edema volume and the rate of writhing as a nociceptive response. These results indicate positive effects of P. nitida extract and its potential to inhibit metabolic syndrome.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Folhas de Planta / Passiflora / Diabetes Mellitus Experimental / Hipoglicemiantes / Anti-Inflamatórios / Antioxidantes Limite: Animals Idioma: En Revista: Appl Biochem Biotechnol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Folhas de Planta / Passiflora / Diabetes Mellitus Experimental / Hipoglicemiantes / Anti-Inflamatórios / Antioxidantes Limite: Animals Idioma: En Revista: Appl Biochem Biotechnol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos