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Hydrochlorothiazide and high-fat diets reduce plasma magnesium levels and increase hepatic oxidative stress in rats.
Ribeiro, Marinei Cristina Pereira; Avila, Daiana Silva de; Barbosa, Nilda Berenice de Vargas; Meinerz, Daiane Francine; Waczuk, Emily Pansera; Hassan, Waseem; Rocha, João Batista Teixeira.
Afiliação
  • Ribeiro MC; Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil. jbtrocha@yahoo.com.br
Magnes Res ; 26(1): 32-40, 2013.
Article em En | MEDLINE | ID: mdl-23657239
This study was designed to develop a rodent model of hydrochlorothiazide (HCTZ) toxicity by associating its intake with a high-fat (HF) diet. Rats were fed for 16 weeks with a control diet or with an HF diet supplemented or not with different doses of HCTZ. HCTZ, in a similar way to the HF diet, caused a significant increase in fructosamine levels. HCTZ and HF diet intake caused a significant reduction in magnesium and potassium levels, as well as an increase in lipid peroxidation and vitamin C in liver. Importantly, negative correlations were found between magnesium and glucose levels as well as between magnesium and fructosamine levels. The association between HCTZ and the HF diet caused additional worsening of biochemical parameters related to glucose homeostasis, and further increased hepatic oxidative stress. Our results suggest that chronic intake of HCTZ or an HF diet causes metabolic changes that are consistent with the development of insulin resistance. In addition, the association of an HF diet and HCTZ treatment can exacerbate some of these biochemical alterations, suggesting that this model might be useful for studying HCTZ metabolic toxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Dieta Hiperlipídica / Hidroclorotiazida / Fígado / Magnésio Limite: Animals Idioma: En Revista: Magnes Res Assunto da revista: FARMACOLOGIA / METABOLISMO / TERAPIA POR MEDICAMENTOS Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Dieta Hiperlipídica / Hidroclorotiazida / Fígado / Magnésio Limite: Animals Idioma: En Revista: Magnes Res Assunto da revista: FARMACOLOGIA / METABOLISMO / TERAPIA POR MEDICAMENTOS Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido