Early confocal microscopy findings after cross-linking treatment.
Arch Soc Esp Oftalmol
; 88(5): 179-83, 2013 May.
Article
em En, Es
| MEDLINE
| ID: mdl-23623018
OBJECTIVE: To determine the effects of in vivo cross-linking treatment of the cornea. METHODS: Eighteen eyes of eighteen keratoconus patients underwent cross-linking treatment using a 0.1% riboflavin solution and ultraviolet A radiation at 370 nm at 3 mW/cm² for 30 minutes. In vivo confocal microscopy was performed before, and at 1 week and 1 month after treatment. RESULTS: At 1 week after treatment, keratocyte activation and collagen fiber organization showed as hyper-reflective structures and were observed from the first sub-epithelial image to a corneal stromal depth of 275.1 ± 85.9 µm. At 1 month after treatment, activated keratocytes and fiber organization were also observed from the first sub-epithelial image to a corneal stromal depth of 324.9 ± 66.0 µm. The deepest hyper-reflective structures at 1 month showed as thick, linear-shaped hyper-reflective structures. CONCLUSION: In vivo confocal microscopy in humans showed corneal stromal changes at 1 week and 1 month after cross-linking treatment, in some cases at depths in excess of 300 µm.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Riboflavina
/
Terapia Ultravioleta
/
Fármacos Fotossensibilizantes
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Microscopia Confocal
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Reagentes de Ligações Cruzadas
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Ceratocone
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
Idioma:
En
/
Es
Revista:
Arch Soc Esp Oftalmol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Espanha