Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194.
J Nat Prod
; 76(4): 741-4, 2013 Apr 26.
Article
em En
| MEDLINE
| ID: mdl-23560689
Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC50 values in the range 0.60-0.78 µM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Alcaloides
/
Antineoplásicos
Limite:
Humans
País/Região como assunto:
America central
/
Panama
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Panamá
País de publicação:
Estados Unidos