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XRCC2 R188H (rs3218536), XRCC3 T241M (rs861539) and R243H (rs77381814) single nucleotide polymorphisms in cervical cancer risk.
Pérez, Luis Orlando; Crivaro, Andrea; Barbisan, Gisela; Poleri, Lucia; Golijow, Carlos Daniel.
Afiliação
  • Pérez LO; IGEVET-CONICET-Institute of Veterinary Genetics-National Council of Scientific and Technical Investigations, Faculty of Veterinary Genetics, University of La Plata, 60th and 118th Street, PC B1900, La Plata, Buenos Aires, Argentina. perezlo@gmail.com
Pathol Oncol Res ; 19(3): 553-8, 2013 Jul.
Article em En | MEDLINE | ID: mdl-23539294
Human Papillomavirus (HPV) is the main cause of cervical cancer and its precursor lesions. Transformation may be induced by several mechanisms, including oncogene activation and genome instability. Individual differences in DNA damage recognition and repair have been hypothesized to influence cervical cancer risk. The aim of this study was to evaluate whether the double strand break gene polymorphisms XRCC2 R188H G>A (rs3218536), XRCC3 T241M C>T (rs861539) and R243H G>A (rs77381814) are associated to cervical cancer in Argentine women. A case control study consisting of 322 samples (205 cases and 117 controls) was carried out. HPV DNA detection was performed by PCR and genotyping of positive samples by EIA (enzyme immunoassay). XRCC2 and 3 polymorphisms were determined by pyrosequencing. The HPV-adjusted odds ratio (OR) of XRCC2 188 GG/AG genotypes was OR = 2.4 (CI = 1.1-4.9, p = 0.02) for cervical cancer. In contrast, there was no increased risk for cervical cancer with XRCC3 241 TT/CC genotypes (OR = 0.48; CI = 0.2-1; p = 0.1) or XRCC3 241 CT/CC (OR = 0.87; CI = 0.52-1.4; p = 0.6). Regarding XRCC3 R243H, the G allele was almost fixed in the population studied. In conclusion, although the sample size was modest, the present data indicate a statistical association between cervical cancer and XRCC2 R188H polymorphism. Future studies are needed to confirm these findings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Proteínas de Ligação a DNA Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Pathol Oncol Res Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Proteínas de Ligação a DNA Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Pathol Oncol Res Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça