Efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in Honduras.
Am J Trop Med Hyg
; 88(5): 850-4, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23458957
Chloroquine (CQ) is officially used for the primary treatment of Plasmodium falciparum malaria in Honduras. In this study, the therapeutic efficacy of CQ for the treatment of uncomplicated P. falciparum malaria in the municipality of Puerto Lempira, Gracias a Dios, Honduras was evaluated using the Pan American Health Organization-World Health Organization protocol with a follow-up of 28 days. Sixty-eight patients from 6 months to 60 years of age microscopically diagnosed with uncomplicated P. falciparum malaria were included in the final analysis. All patients who were treated with CQ (25 mg/kg over 3 days) cleared parasitemia by day 3 and acquired no new P. falciparum infection within 28 days of follow-up. All the parasite samples sequenced for CQ resistance mutations (pfcrt) showed only the CQ-sensitive genotype (CVMNK). This finding shows that CQ remains highly efficacious for the treatment of uncomplicated P. falciparum malaria in Gracias a Dios, Honduras.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Plasmodium falciparum
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Proteínas de Protozoários
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Cloroquina
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Malária Falciparum
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Antimaláricos
Tipo de estudo:
Guideline
Limite:
Adolescent
/
Adult
/
Child
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Child, preschool
/
Female
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Humans
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Infant
/
Male
/
Middle aged
País/Região como assunto:
America central
/
Honduras
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Honduras
País de publicação:
Estados Unidos