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Neurotoxic effects of intrathecal magnesium sulphate.
Ozdogan, Levent; Sastim, Handan; Ornek, Dilsen; Postaci, Aysun; Ayerden, Taner; Dikmen, Bayazit.
Afiliação
  • Ozdogan L; Anaesthesia and Reanimation Department, Ankara Numune Training and Research Hospital, Turkey.
Braz J Anesthesiol ; 63(1): 139-43, 2013.
Article em En | MEDLINE | ID: mdl-23438808
BACKGROUND AND OBJECTIVES: To assess the potential neurotoxic effects at the ultrastructural level of magnesium sulfate administered intrathecally as a single or multi-dose. METHODS: Our study was conducted with 24 Sprague-Dawley rats that weighed 250-300 g. After a 4-hour fast, the rats were given 10 mg.kg(-1) xylazine chloride intraperitoneal and then randomly allocated into three groups. Group I (n=8) received 0.9% normal saline, Group II (n = 8) was given one intrathecal injection of 0.02 mL of 15% magnesium sulphate, and Group III (n = 8) was given 0.02 mL of 15% magnesium sulphate once a day for seven days. The injections were given within 0.40 × 50 mm from the lumbar area. After seven days, the animals were sacrificed under anesthesia with an aortic injection of 10% formaldehyde and their tissues were fixed. The medulla spinalis was then examined and histopathologically evaluated under an electron microscope. The Kruskal-Wallis test was used for statistical evaluation. A value of p < .05 was considered to be statistically significant. RESULTS: Significant neurodegeneration was detected in rats given single or repeated magnesium sulphate injections compared to the control group. The histopathological evaluation score of this group was also high. CONCLUSIONS: Based on electron microscopic examination, we found that intrathecal magnesium sulphate administration induced neurodegeneration.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Espinal / Síndromes Neurotóxicas / Anestésicos / Sulfato de Magnésio Limite: Animals Idioma: En Revista: Braz J Anesthesiol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Espinal / Síndromes Neurotóxicas / Anestésicos / Sulfato de Magnésio Limite: Animals Idioma: En Revista: Braz J Anesthesiol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil