[Dark urine and jaundice as warning signs in Plasmodium falciparum malaria in Colombia]. / Orina oscura e ictericia como signos de peligro en malaria por Plasmodium falciparum en Colombia.
Rev Cubana Med Trop
; 62(1): 28-35, 2010.
Article
em Es
| MEDLINE
| ID: mdl-23431634
INTRODUCTION: early recognition of warning signs in malarial patients allows timely identification of the patient at risk of severe malaria and provides opportune treatment. Jaundice and dark urine are frequent signs that can alert to the occurrence of severe malaria. OBJECTIVE: to study the relationship between jaundice and dark urine with impaired liver and/or kidney function and anemia in malarial patients, and explore their role as warning signs. METHOD: clinical and laboratory data from 199 patients with Plasmodium falciparum malaria, belonging to a case control study conducted in Colombia, were analyzed, the association between dark urine and jaundice with impairment in the urine analysis, the hepatic and renal function test, and hemoglobin were studied. RESULTS: there was association between dark urine and hemoglobinuria (OR = 236, 63-867), hematuria (OR = 3.2, 1.6-6.6), proteinuria (OR = 2.3, 1-5.3) and bilirubinuria (OR = 2.1, 1-4.4). Jaundice was present in 31 % of patients who had renal dysfunction (OR = 2.7, 1.1-6.4) and in 22 % of those with liver dysfunction (OR = 2.1, 0.9-4.5). Jaundice was more likely in patients with total bilirubin > 25.6 micromol/L (OR = 6.1, 2.7-13.4) and blood ureic nitrogen > 7.14 mmol/L (OR = 3.5, 1.4-8.5). CONCLUSIONS: jaundice in patients with malaria may be considered as a warning sign associated with liver and kidney dysfunction. Dark urine was not associated with kidney or liver dysfunction, but was related to bilirubinuria, hematuria and proteinuria, which can be early indicators of failure; dark urine must be studied to clarify its relationship with liver and kidney failure in malaria.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Malária Falciparum
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
America do sul
/
Colombia
Idioma:
Es
Revista:
Rev Cubana Med Trop
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Colômbia
País de publicação:
Cuba