[Impact of highly active antiretroviral therapy in the clinical, immunological and virological response from AIDS patients]. / Impacto de la terapia antirretroviral de alta eficacia en la respuesta clinica e inmunovirológica en enfermos SIDA.
Rev Cubana Med Trop
; 59(2): 139-48, 2007.
Article
em Es
| MEDLINE
| ID: mdl-23427448
A longitudinal prospective study was made to evaluate the clinical, immunological and virological response of a cohort of 34 AIDS patients in Cienfuegos provinces, who had been treated with highly active antiretroviral therapy (HAART). Males comprised 67.6% of the total number and average age was 32 years. Sexual infection path was identified in 91.2% of cases. The CD4+ T counting under 200 cells defined AIDS in 79.4% of individuals. Twenty six patients suffered minor opportunistic infections (76.5%) whereas 32.4% got sick due to some major opportunistic disease prior to the therapy. After this therapy, these frequencies lowered to 20.6% and 11.8% respectively. Average CD4+ counting at the starting of HAART was 196 cell/mm3 and exceeded 400 cells in the rest of further countings. From a PVC average of 15 251 copies/mL one year after therapy, this figure reduced to 8 048 copies at 2 years. Only 10 cases required hospitalization after a HAART (29.4%). Treatment adherence reached over 80% and was correlated to immunological restoration. Survival after one year was 100% and only 2 patients died in the following 4 years. The positive impact of HAART on the frequency of opportunistic infections, immunological restoration and survival was proved.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azatioprina
/
Viremia
/
Síndrome da Imunodeficiência Adquirida
/
Estavudina
/
Lamivudina
/
Fármacos Anti-HIV
/
Terapia Antirretroviral de Alta Atividade
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Caribe
/
Cuba
Idioma:
Es
Revista:
Rev Cubana Med Trop
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Cuba