Your browser doesn't support javascript.
loading
Boron neutron capture therapy for oral precancer: proof of principle in an experimental animal model.
Monti Hughes, A M; Pozzi, E C C; Thorp, S; Garabalino, M A; Farías, R O; González, S J; Heber, E M; Itoiz, M E; Aromando, R F; Molinari, A J; Miller, M; Nigg, D W; Curotto, P; Trivillin, V A; Schwint, A E.
Afiliação
  • Monti Hughes AM; Department of Radiobiology, National Atomic Energy Commission (CNEA), San Martin, Argentina.
Oral Dis ; 19(8): 789-95, 2013 Nov.
Article em En | MEDLINE | ID: mdl-23410091
OBJECTIVES: Field-cancerized tissue can give rise to second primary tumours, causing therapeutic failure. Boron neutron capture therapy (BNCT) is based on biological targeting and would serve to treat undetectable foci of malignant transformation. The aim of this study was to optimize BNCT for the integral treatment for oral cancer, with particular emphasis on the inhibitory effect on tumour development originating in precancerous conditions, and radiotoxicity of different BNCT protocols in a hamster cheek pouch oral precancer model. MATERIALS AND METHODS: Groups of cancerized hamsters were locally exposed to single or double (2 or 4 weeks apart) applications of BNCT at different dose levels, mediated by the boron compounds boronophenylalanine (BPA) or BPA and decahydrodecaborate (GB-10) administered jointly. Cancerized, sham-irradiated hamsters served as controls. Clinical status, tumour development from field-cancerized tissue and mucositis were followed for 8 months. RESULTS: A double application (4 weeks apart) of BNCT mediated by GB-10+ BPA at a total dose of 10 Gy in two 5-Gy doses rendered the best therapeutic advantage (63-100% inhibition of tumour development from field-cancerized tissue), minimizing dose-limiting mucositis. CONCLUSION: BNCT can be optimized for the integral treatment for head and neck cancer, considering the implications for field-cancerized tissue.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Neoplasias Bucais / Terapia por Captura de Nêutron de Boro Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Oral Dis Assunto da revista: ODONTOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Argentina País de publicação: Dinamarca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Neoplasias Bucais / Terapia por Captura de Nêutron de Boro Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Oral Dis Assunto da revista: ODONTOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Argentina País de publicação: Dinamarca