Aggressive transformation of juvenile myelomonocytic leukemia associated with duplication of oncogenic KRAS due to acquired uniparental disomy.
J Pediatr
; 162(6): 1285-8, 1288.e1, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23403250
A small fraction of cases of juvenile myelomonocytic leukemia (JMML) develop massive disease activation. Through genomic analysis of JMML, which developed in an individual with mosaicism for oncogenic KRAS mutation with rapid progression, we identified acquired uniparental disomy at 12p. We demonstrated that duplication of oncogenic KRAS is associated with rapid JMML progression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus Oncogênicos
/
Proteínas Proto-Oncogênicas
/
Proteínas ras
/
Dissomia Uniparental
/
Leucemia Mielomonocítica Juvenil
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Infant
/
Male
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão
País de publicação:
Estados Unidos