Effects of a Palicourea marcgravii leaf extract on some dopamine-related behaviors of rats.
J Ethnopharmacol
; 28(3): 329-35, 1990 Mar.
Article
em En
| MEDLINE
| ID: mdl-2335961
The effects of a Palicourea marcgravii leaf extract on some dopamine-related behaviors were studied in rats. The extract given subcutaneously decreased both spontaneous locomotion and rearing frequencies of rats observed in open-field studies and increased their periods of immobility. The extract was also able to produce a rightward displacement of the apomorphine dose-response curve for stereotyped behavior and decrease the maximum response possible. Although the extract (1.87 g/kg subcutaneously) was unable to produce true catalepsy by itself, it potentiated that induced by haloperidol. These results with the extract can be interpreted to be due to a direct blocking action for the extract on a mesostriatal dopamine receptor or to an indirect effect on dopamine pathways through central cholinergic activation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Irlanda