[Targeted epigenetic therapy of cancer. Achievements and perspectives]. / Terapia epigenética en el cáncer. Logros y perspectivas.
Cir Cir
; 80(5): 470-80, 2012.
Article
em Es
| MEDLINE
| ID: mdl-23351455
In this review, we provide an overview of the physiological and pathophysiological epigenetic changes of normal cells and cancer cells, and emphasize the achievements and the perspectives of cancer epigenetic therapy. Cancer epigenetic alterations correspond foremost to hypermethylation of tumor suppressor genes promotors, global DNA hypomethylation, and overexpression and activity of histone deacetylases. The purpose of epigenetic therapy is to revert the epigenetic alterations in cancer cells and obtain the "normal epigenome" restoration. Epigenetic targets in cancer therapy have focused on HDACs and DNMTs inhibition. The azacitidine and the decitabine, the vorinostat and the romidepsin were approved by US-FDA for treatment of myelodysplastic syndrome, and cutaneous T-cell lymphoma, respectively. Epigenetic and epigenomic changes in single or multiple genes have showed potential impact in cancer as early detection, prognosis and predictive marks. The epigenetic revolution has arrived for biology. The significant progress in epigenetic studies have allowed us, to understand new looks in the physiology and pathophysiology of embryonic development, cancer and other chronic diseases. Specific molecular epigenetic alterations in different cancer types, give us new strategies to design improved cancer therapy. The challenge for epigenetic investigators is design more specific epidrugs with lesser side effects.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Regulação Neoplásica da Expressão Gênica
/
Metilação de DNA
/
Epigênese Genética
/
DNA (Citosina-5-)-Metiltransferases
/
Inibidores de Histona Desacetilases
/
Terapia de Alvo Molecular
/
Neoplasias
Tipo de estudo:
Prognostic_studies
/
Screening_studies
Limite:
Humans
Idioma:
Es
Revista:
Cir Cir
Ano de publicação:
2012
Tipo de documento:
Article
País de publicação:
México