Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy.
Genet Mol Res
; 11(4): 4256-67, 2012 Dec 17.
Article
em En
| MEDLINE
| ID: mdl-23315805
We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ratios (ORs) with 95% confidence intervals (95%CIs). We found that elevated PCV risk was significantly associated with the GG genotype (GG vs TT, OR = 4.23, 95%CI = 3.53-5.06), and heterozygous genotype TG appeared to have a minor effect on PCV risk (TG vs TT, OR = 1.47, 95%CI = 1.26-1.71). Patients with the T allele were 2.09 times more likely to have PCV than those with the G allele (95%CI = 1.906-2.288). A further subgroup analysis by ages also showed that the genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV is stronger among patients with mean age <73 years. Our meta-analysis strengthened the evidence that the LOC387715/ARMS2 rs10490924 G>T polymorphism plays an important role in PCV susceptibility.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Vasculares
/
Proteínas
/
Doenças da Coroide
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Genet Mol Res
Assunto da revista:
BIOLOGIA MOLECULAR
/
GENETICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Brasil